Applied Mycology and Biotechnology

Most industrial processes used fungal cells for the bulk manufacturing of organic acids, proteins, enzymes, secondary metabolites and active pharmaceutical ingredients in white and red biotechnology. Fungi are also significantly impacting on global food security, damaging global crop production, causing disease in domesticated animals, and spoiling an estimated 10 % of harvested crops. A number of challenges now need to be addressed to improve our strategies to control fungal pathogenicity and to optimise the use of fungi as sources for novel compounds. Some of these products are produced commercially while others are potentially valuable in biotechnology. The secondary metabolites of fungi have extreme importance to health and nutrition and have tremendous economic impact. In addition to the multiple reaction sequences of fermentations, fungi are extremely useful in carrying out biotransformation processes. These are becoming essential to the fine-chemical industry in the production of single-isomer intermediates. rDNA technology, which includes yeasts and other fungi as hosts, has markedly increased markets for microbial enzymes. Molecular manipulations have been added to mutational techniques as a means of increasing yields of microbial processes and in the discovery of new drugs. Nowadays, fungal biology is a major contributor in global industry. Still, the finest is yet to come as genomes of new additional species have located and sequenced at some level (cDNA, complete genomes, and expressed sequence tags) and gene and protein arrays will become available.

  • Marine mycotechnology
  • Fungal metabolites
  • Genetic engineering of filamentous fungi
  • Fungal leaching
  • Fungal use in control of pests and pathogens
  • Yeast and synthetic biology

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